After structural changes in the national centre of manuscripts, there had been established following departments and offices:
- Board of Directors (Management)
- Organizational department
- Department of clerical work
- Department of financial and material resources
- Office of finances and accounting
- Office of material-technical maintenance
- Office of centre purchases
- Department of scientific collaboration, projects and public relations
- Office of Public relations and cultural programmes
- Office of foreign affairs and translation
- Department of science, analytics and publications
- Publishing office
- Department of oriental and Armenian manuscripts
- Department of Codicology and Textology
- Department of Diplomatics and source criticism
- Department of art criticism
- Department of archival studies and electronic archive
- Department of scientific bibliography, terminology and informational literature
- Department of manuscript preservation and registration
- Office of conservation and restoration
- Department of exhibition-educational programmes and marketing
- Department of library museums
- Office of memorial museum-cabinets
laboratory:
- Laboratory of Digitalization